Platinum-induced neurotoxicity: A review of possible mechanisms
نویسندگان
چکیده
منابع مشابه
Platinum-induced neurotoxicity: A review of possible mechanisms
Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despite discontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is ...
متن کاملMechanisms of vincristine-induced neurotoxicity: Possible reversal by erythropoietin.
Vincristine (VCR) is a potent anticancer drug, but neurotoxicity is one of its most important dose-limiting toxicities. In this study, we investigated the neurotoxic effect of VCR, the possible mechanisms and the role of erythropoietin (EPO) in the protection against VCR-induced neurotoxicity in a rat model. The neurotoxicity of VCR and protective effect of EPO were examined using the tail flic...
متن کاملMechanisms of methylmercury-induced neurotoxicity.
Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of C...
متن کاملCurrent View in Platinum Drug Mechanisms of Peripheral Neurotoxicity
Peripheral neurotoxicity is the dose-limiting factor for clinical use of platinum derivatives, a class of anticancer drugs which includes cisplatin, carboplatin, and oxaliplatin. In particular cisplatin and oxaliplatin induce a severe peripheral neurotoxicity while carboplatin is less neurotoxic. The mechanisms proposed to explain these drugs' neurotoxicity are dorsal root ganglia alteration, o...
متن کاملFluoroquinolone Induced Neurotoxicity: A Review
Introduction: Fluoroquinolones (FQs) are commonly used antibiotics both in inpatient and outpatient settings. Their therapeutic use ranges from the common respiratory, urinary tract and gastrointestinal infections to management of drug resistant tuberculosis and febrile neutropenia in immunocompromised patients. [1] Significant features of this group of antibiotics include their wide antibacter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Clinical Oncology
سال: 2017
ISSN: 2218-4333
DOI: 10.5306/wjco.v8.i4.329